Cook the pasta: Boil the macaroni in salted water until just al dente. Drain and set aside.
Make the cheese sauce: Melt butter in a saucepan over medium heat. Whisk in flour and cook 1 minute. Slowly whisk in warm heavy cream and water. Stir until thickened, about 3-4 minutes. Remove from heat and stir in cheddar, mozzarella, Parmesan, Dijon, garlic powder, salt, and pepper.
Assemble: Stir the drained pasta into the cheese sauce. Divide into 2 small pie dishes.
Add topping: Mix panko, melted butter, and Parmesan. Sprinkle over the mac.
Bake at 375°F (190°C) for 15-20 minutes, until bubbly and golden on top.